Not sure how this falls in with yesterday’s news about blood glucose spikes if it does at all, but a team of researchers at Chiba University in Japan have found a protein that plays into diabetes coming from heart disease. In this case, it’s heart disease leading to diabetes, not the other way around. This time, heart disease stress activates a protein called p53 or “upregulates” it meaning there is more than should be there. This activates the p53 protein residing in fatty tissues. Too much p53 causes inflammation in the fatty tissues.
Because the tissues are overloaded with p53, it accelerates lipolysis or the breakdown of the fatty tissues into fatty acids and more (eventually). As the fat is broken down by lipolysis (normal bodily function), we end up with increased insulin resistance because there is too much. This not only may lead to diabetes but also to a worsening heart condition.
So at its basics, it produces a domino effect by producing more inflammation in fat and increased insulin resistance which leads to more problems with the heart.
This is what might play into the news from yesterday. By doing things which improve insulin resistance, you improve the outlook for people who are suffering from heart failure. So you need to do things that stop those blood glucose spikes in order to minimize the chances of increasing insulin resistance.
As stress to the heart was mentioned as one of the causes, doing what you can to lower your stress and stress on your heart (which happens different ways) would be a very good thing.
In the meantime, inhibiting lipolysis has a positive effect on both p53 and inflammation. And disrupting p53 activation lowered inflammation and improved insulin resistance which lessened cardiac problems. But there are other problems.
This protein p53 is a “cellular aging agent” according to one of the study’s authors, Tohru Minamino. It builds up in the heart due to stress or aging and may lead to heart failure. That was all found in previous research.
The catch is that this protein also has tumor fighting properties. So knowing how it plays into heart disease and diabetes as well as tumor fighting means the researchers will need something that keeps the inflammation down but allows p53 to keep fighting tumors. Sounds like they have their work cut out for them.
The first one was aspirin reducing the risk of breast cancer especially that which was stimulated by estrogen. Different studies reported findings differently but one said that women who used aspirin at least once a week for six month or longer had a 20% less chance of getting breast cancer.
Likewise a different study on post-menopausal women found those who had regularly taken NSAIDs for more than 10 years cut their chances for breast cancer by 28%.
Other cancers aspirin fights are colon cancer (40% less risk), esophageal cancer (cuts by 50%), and ovarian cancer (by 40% for those taking it at least 3 times a week for over 6 months).
Just remember some people do have stomach bleeding with use of aspirin which is one reason I try to stay away from NSAIDs myself. But maybe one little 81 milligram a day might not be too much if the above are the benefits to be derived?
Like everything you read about your health and anti-aging, check with your own doctor before beginning to use, do or whatever.